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Dr. Parag Kolhe

PhD Graduate

Parag Kolhe graduated with his PhD in Chemical Engineering from Wayne State University in 2005. He finished his B.S. in Polymer Engineering from Maharashtra Institute of Technology, Pune, India in 1999 where he graduated with highest honors.

He joined Wayne State University in Fall 99 where is initial work was in the development of a new biomaterial for application in tissue engineering. He studied the mechanical properties of blends of chitosan and polyethylene glycol and characterized the molecular interactions using FTIR and X-ray diffractions. This work has been published in Biomacromolecules.

Major part of his PhD thesis involved synthesis, characterization of dendrimer/hyperbranched polymer based drug delivery system. He deals with chemical synthesis of conjugates/complexes of dendrimer/hyperbranched polymer for specific application in inflammation, cancer and asthma. The results obtained with these studies have been published in International Journal of Pharmaceutics and Journal of biomaterial science: polymer edition.

    Dr. Kolhe's Publications
  • 'Preparation, cellular transport, and activity of polyamidoamine-based dendritic nanodevices with a high drug payload', P. Kolhe, J. Khandare, O. Pillai, S. Kannan, M. Lieh-Lai, R. M. Kannan, BIOMATERIALS 27 (4): 660-669 FEB 2006

  • 'Synthesis, Cellular Transport and Activity of PAMAM Dendrimer-Methylprednisolone Conjugates', J. Khandare, P. Kolhe, O. Pillai, S. Kannan, M. Lieh-Lai, R. M. Kannan, Bioconjugate Chemistry, 16 (2), 330 -337, 2005

  • 'Hyperbranched polymer-drug conjugates with high drug payload for enhanced cellular delivery ', P. Kolhe, J. Khandare, O. Pillai, S. Kannan, M. Lieh-Lai, R. M. Kannan, Pharm. Research, 21(12), 2185-2195 (2004)

  • 'Effect of dendrimer end functionality on the cytotoxicity and the cellular drug delivery in lung epithelial cells', S. Kannan, P. Kolhe, R. M. Kannan, M. Lieh-lai, M. Glibatec, Journal of Biomaterials Science: Polymers Edition, 15(3), 311 (2004)

  • 'Improvement in ductility of chitosan through blending and copolymerization with PEG: FTIR investigation of molecular interactions ', P. Kolhe and R. M. Kannan, Biomacromolecules, Vol. 4 (1), 173-180 (2003)

  • 'Drug complexation, in vitro release, and cellular entry by dendrimers and hyperbranched polymers', P. Kohle, E. Misra, R. M.Kannan, S. Kannan, M. Lieh-Lai, International Journal of Pharmaceutics, 259, 143-160 (2003)