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Peer-Reviewed Publications

2008- to date

[38] 'Nanomedicine in cerebral palsy'.B Balakrishnan, E Nance, MV Johnston, RM Kannan, S Kannan* (2013). International Journal of Nanomedicine, Invited Review, in press.

[37] 'Biodistribution of Fluorescently-labeled PAMAM Dendrimers in Neonatal Rabbits: Effect of Neuroinflammation'.W Lesniak, MK Mishra, A Jyoti, B Balakrishnan, F Zhang, E Nance, R Romero, S Kannan, RM Kannan* (2013). Molecular pharmaceutics, [Epub ahead of print] DOI: 10.1021/mp400371r

[36] 'Concurrent quantification of tryptophan and its major metabolites'.WG Lesniak, A Jyoti, MK Mishra, N Louissaint, R Romero, DC Chugani, S Kannan, RM Kannan* (2013). Analytical biochemistry, [Epub ahead of print] pii: S0003-2697(13)00423-5. doi: 10.1016/j.ab.2013.09.001.

[35] 'Dendrimer-enabled transformation of Chlamydia trachomatis'.RM Kannan, HC Gerard, MK Mishra, G Mao, S Wang, M Hali, JA Whittum-Hudson, AP Hudson (2013). Microbial pathogenesis, 65C 29-35.

[34] 'Dendrimer-enabled DNA delivery and transformation of Chlamydia pneumoniae'.HC Gerard, MK Mishra, G Mao, S Wang, M Hali, JA Whittum-Hudson, RM Kannan*, AP Hudson* (2013). Nanomedicine: nanotechnology, biology, and medicine, 9(7), 996-1008.

[33] 'Dendrimer nanoparticles for ocular drug delivery'.SP Kambhampati, RM Kannan* (2013). Journal of ocular pharmacology and therapeutics: the official journal of the Association for Ocular Pharmacology and Therapeutics, 29(2), 151-165.

[32] 'Nanotechnology approaches for ocular drug delivery'.Q Xu, SP Kambhampati, RM Kannan* (2013). Middle East African journal of ophthalmology, 20(1), 26-37.

[31] 'Use of Single-Site-Functionalized PEG Dendrons To Prepare Gene Vectors that Penetrate Human Mucus Barriers'.AJ Kim, NJ Boylan, JS Suk, M Hwangbo, T Yu, BS Schuster, L Cebotaru, WG Lesniak, JS Oh, P Adstamongkonkul, AY Choi, RM Kannan, J Hanes* (2013). Angewandte Chemie International Edition, 52(14), 3985-3988.

[30] 'Enhancing the efficacy of Ara-C through conjugation with PAMAM dendrimer and linear PEG: a comparative study'.UH Sk, SP Kambhampati, MK Mishra, WG Lesniak, F Zhang, RM Kannan* (2013). Biomacromolecules, 14(3), 801-810.

[29] 'Dendrimer-based postnatal therapy for neuroinflammation and cerebral palsy in a rabbit model'.S Kannan*, H Dai, RS Navath, B Balakrishnan, A Jyoti, J Janisse, R Romero, RM Kannan* (2012). Science translational medicine, 4(130), 130ra146.

[28] 'Dendrimer-based targeted intravitreal therapy for sustained attenuation of neuroinflammation in retinal degeneration'.R Iezzi, BR Guru, IV Glybina, MK Mishra, A Kennedy, RM Kannan* (2012). Biomaterials, 33(3), 979-988.

[27] 'A dendrimer-based immunosensor for improved capture and detection of tumor necrosis factor-alpha cytokine'.A Bosnjakovic, MK Mishra, HJ Han, R Romero, RM Kannan* (2012). Analytica chimica acta, 720 118-125.

[26] 'Dendrimer-enabled modulation of gene expression in Chlamydia trachomatis'.MK Mishra, HC Gerard, JA Whittum-Hudson, AP Hudson, RM Kannan* (2012). Molecular pharmaceutics, 9(3), 413-421.

[25] 'Injectable PAMAM dendrimer-PEG hydrogels for the treatment of genital infections: formulation and in vitro and in vivo evaluation'.RS Navath, AR Menjoge, H Dai, R Romero, S Kannan, RM Kannan* (2011). Molecular pharmaceutics, 8(4), 1209-1223.

[24] 'PAMAM dendrimer-azithromycin conjugate nanodevices for the treatment of Chlamydia trachomatis infections'.MK Mishra, K Kotta, M Hali, S Wykes, HC Gerard, AP Hudson, JA Whittum-Hudson, RM Kannan* (2011). Nanomedicine: nanotechnology, biology, and medicine, 7(6), 935-944.

[23] 'Transfer of PAMAM dendrimers across human placenta: Prospects of its use as drug carrier during pregnancy'.AR Menjoge, AL Rinderknecht, RS Navath, M Faridnia, CJ Kim, R Romero, RK Miller, RM Kannan* (2011). Journal of Control Release, 150(3), 326-338.

[22] 'Poly(amidoamine) dendrimer-erythromycin conjugates for drug delivery to macrophages involved in periprosthetic inflammation'.A Bosnjakovic, MK Mishra, W Ren, YE Kurtoglu, T Shi, D Fan, RM Kannan* (2011). Nanomedicine: nanotechnology, biology, and medicine, 7(3), 284-294.

[21] 'Supercritical carbon dioxide processed resorbable polymer nanocomposite bone graft substitutes'.KC Baker, M Manitiu, R Bellair, CA Gratopp, HN Herkowitz, RM Kannan* (2011). Acta biomaterialia, 7(9), 3382-3389.

[20] 'Intrinsic targeting of inflammatory cells in the brain by polyamidoamine dendrimers upon subarachnoid administration'.H Dai, RS Navath, B Balakrishnan, BR Guru, MK Mishra, R Romero, RM Kannan*, S Kannan (2010). Nanomedicine : nanotechnology, biology, and medicine, 5(9), 1317-1329.

[19] 'In vivo efficacy of dendrimer-methylprednisolone conjugate formulation for the treatment of lung inflammation'.R Inapagolla, BR Guru, YE Kurtoglu, X Gao, M Lieh-Lai, DJ Bassett, RM Kannan* (2010). International journal of pharmaceutics, 399(1-2), 140-147.

[18] 'Inhibition of bacterial growth and intramniotic infection in a guinea pig model of chorioamnionitis using PAMAM dendrimers'. B Wang, RS Navath, AR Menjoge, B Balakrishnan, R Bellair, H Dai, R Romero, S Kannan, RM Kannan* (2010).International journal of pharmaceutics, 395(1-2), 298-308.

[17] 'Amino Acid-Functionalized Dendrimers with Heterobifunctional Chemoselective Peripheral Groups for Drug Delivery Applications'.RS Navath, AR Menjoge, B Wang, R Romero, S Kannan, RM Kannan* (2010). Biomacromolecules, 11(6), 1544-1563.

[16] 'Transport and biodistribution of dendrimers across human fetal membranes: Implications for intravaginal administration of dendrimer-drug conjugates'.AR Menjoge, RS Navath, A Asad, S Kannan, CJ Kim, R Romero, RM Kannan* (2010). Biomaterials, 31(18), 5007-5021.

[15] 'Investigation of Clay Modifier Effects on the Structure and Rheology of Supercritical Carbon Dioxide-Processed Polymer Nanocomposites'.RJ Bellair, M Manitiu, E Gulari, RM Kannan* (2010). Journal of Polymer Science Polymer Physics, 48(8), 823-831.

[14] 'Reversal of Methylprednisolone Effects in Allergen-Exposed Female Balb/c Mice'.D Bassett, F Hirata, XF Gao, R Kannan, J Kerr, N Doyon-Reale, S Wilson, M Lieh-Lai (2010). Journal of Toxicology and Environmental Health Part A, 73(11), 711-724.

[13] 'Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications'.AR Menjoge, RM Kannan*, DA Tomalia (2010). Drug Discovery Today, 15(5-6), 171-185.

[12] 'Stimuli-responsive star poly(ethylene glycol) drug conjugates for improved intracellular delivery of the drug in neuroinflammation'.RS Navath, B Wang, S Kannan, R Romero, RM Kannan* (2010). Journal of Control Release, 142(3), 447-456.

[11] 'Multifunctional Dendrimer-Templated Antibody Presentation on Biosensor Surfaces for Improved Biomarker Detection'.HJ Han, RM Kannan*, SX Wang, GZ Mao, JP Kusanovic, R Romero (2010). Advanced Functional Materials, 20(3), 409-421.

[10] 'Drug release characteristics of PAMAM dendrimer-drug conjugates with different linkers'.YE Kurtoglu, MK Mishra, S Kannan, RM Kannan* (2010). International journal of pharmaceutics, 384(1-2), 189-194.

[09] 'Structure and mechanical properties of supercritical carbon dioxide processed porous resorbable polymer constructs'.KC Baker, R Bellair, M Manitiu, HN Herkowitz, RM Kannan* (2009). J Mech Behav Biomed, 2(6), 620-626.

[08] 'Anti-inflammatory and anti-oxidant activity of anionic dendrimer-N-acetyl cysteine conjugates in activated microglial cells'.B Wang, RS Navath, R Romero, S Kannan, R Kannan (2009). International journal of pharmaceutics, 377(1-2), 159-168.

[07] 'Effects of Branching Architecture and Linker on the Activity of Hyperbranched Polymer-Drug Conjugates'.O Perumal, J Khandare, P Kolhe, S Kannan, M Lieh-Lai, RM Kannan* (2009). Bioconjugate Chemistryistry, 20(5), 842-846.

[06] 'Role of polymer-clay interactions and nano-clay dispersion on the viscoelastic response of supercritical CO2 dispersed polyvinylmethylether (PVME)-Clay nanocomposites'.M Manitiu, S Horsch, E Gulari, RM Kannan* (2009). Polymer, 50(15), 3786-3796.

[05] 'Poly(amidoamine) dendrimer-drug conjugates with disulfide linkages for intracellular drug delivery'.YE Kurtoglu, RS Navath, B Wang, S Kannan, R Romero, RM Kannan* (2009). Biomaterials, 30(11), 2112-2121.

[04] 'Dendrimer-drug conjugates for tailored intracellular drug release based on glutathione levels'.RS Navath, YE Kurtoglu, B Wang, S Kannan, R Romero, RM Kannan* (2008). Bioconjugate Chemistry, 19(12), 2446-2455.

[03] 'The effect of surface functionality on cellular trafficking of dendrimers'. OP Perumal, R Inapagolla, S Kannan, RM Kannan* (2008). Biomaterials, 29(24-25), 3469-3476.

[02] 'Engineering strength, porosity, and emission intensity of nanostructured CdSe networks by altering the building-block shape'. H Yu, R Bellair, RM Kannan*, SL Brock (2008). Journal of the American Chemical Society, 130(15), 5054-5055.

[01] 'Supercritical Carbon Dioxide-Processed Dispersed Polystyrene-Clay Nanocomposites'. M Manitiu, RJ Bellair, S Horsch, E Gulari, RM Kannan* (2008). Macromolecules, 41(21), 8038-8046.

2007 and Earlier

[36]'Dendrimers and hyperbranched polymers for drug delivery.', Kannan, Rangaramanujam M.; Perumal, Omathanu P.; Kannan, Sujatha. Biomedical Applications of Nanotechnology (2007), 105-129

[35]'Synthesis, characterization and in vitro release of dendrimer-streptokinase conjugates', X. Wang, R. Inapagolla, M. Lieh-Lai, R. M. Kannan, S. Kannan, Bioconjugate Chem.(2007), 18(3), 791-799

[34]'Cellular interactions of nano drug delivery systems.', Kannan, Rangaramanujam M.; Perumal, Omathanu Pillai; Kannan, Sujatha. Force Microscopy (2006), 113-136

[33] 'Supercritical CO2 dispersion of nano-clays and clay/polymer nanocomposites', S. Horsch, G. Serhatkulu, E. Gulari, R. M. Kannan, Polymer 47 (21) 7485-7496 Oct 4 2006

[32] 'Rheo-optical measurements of the first and third normal stresses of homopolymer polyvinyl methyl ether melt', A. Kulkarni, S. Kharchenko, R. M. Kannan, Rheologica Acta, (2006), 45(6), 951-958

[31] 'Preparation, cellular transport, and activity of polyamidoamine-based dendritic nanodevices with a high drug payload', P. Kolhe, J. Khandare, O. Pillai, S. Kannan, M. Lieh-Lai, R. M. Kannan, BIOMATERIALS 27 (4): 660-669 FEB 2006

[30] 'Vibrational spectroscopic investigation of stereoregularity effects in syndiotactic polypropylene structure and morphology', M. Sevegney, R.M. Kannan, R. Naik, V. Naik, Vibrational Spectroscopy (2006), 40(2), 246-256

[29] 'Synthesis, Cellular Transport and Activity of PAMAM Dendrimer-Methylprednisolone Conjugates', J. Khandare, P. Kolhe, O. Pillai, S. Kannan, M. Lieh-Lai, R. M. Kannan, Bioconjugate Chemistry, 16 (2), 330 -337, 2005

[28] 'Activity of dendrimer-methotrexate conjugates in sensitive and resistant cell lines', S. Gurdag, J. Khandare, S. Staples, R. M. Kannan, L. Matherly, Bioconjugate Chemistry, 17, 275-283, 2005

[27] 'Monitoring elasticity in syndiotactic polypropylene films', G.Parthasarathy, M. Sevegney, R. M. Kannan, POLYMER 46 (17): 6335-6346 AUG 8 2005

[26] 'Supercritical Fluid based process for preparing highly exfoliated nanocomposites', E. Gulari, G.K. Serhatkulu, R. M. Kannan, US patent filed, March 2004

[25] 'A rheo-optical FTIR spectrometer for the investigation of deformation behavior in complex polymers', M. Sevegney, G. Hofmann, R. M. Kannan, ,Int. J. Poly. Anal. Char.(2004) 9, 245-274

[24] 'FTIR Spectroscopic Investigation of Thermal Effects in Semi-Syndiotactic Polypropylene', M. Sevegney, R. M. Kannan, P. Percha, A. Siedle, Journal of Polymer Science(2004) (PP), 43(4), 493-461

[23] 'Hyperbranched polymer-drug conjugates with high drug payload for enhanced cellular delivery ', P. Kolhe, J. Khandare, O. Pillai, S. Kannan, M. Lieh-Lai, R. M. Kannan, Pharm. Research, 21(12), 2185-2195 (2004)

[22] 'Effect of dendrimer end functionality on the cytotoxicity and the cellular drug delivery in lung epithelial cells', S. Kannan, P. Kolhe, R. M. Kannan, M. Lieh-lai, M. Glibatec, Journal of Biomaterials Science: Polymers Edition, 15(3), 311 (2004)

[21] 'Deformation-induced morphology changes and orientation behavior in syndiotactic polypropylene', M. Sevegney, G. Parthasarthy, R. M. Kannan, Macromolecules, 36(17), 6472 (2003)

[20] 'Improvement in ductility of chitosan through blending and copolymerization with PEG: FTIR investigation of molecular interactions ', P. Kolhe and R. M. Kannan, Biomacromolecules, Vol. 4 (1), 173-180 (2003)

[19] 'Drug complexation, in vitro release, and cellular entry by dendrimers and hyperbranched polymers', P. Kohle, E. Misra, R. M.Kannan, S. Kannan, M. Lieh-Lai, International Journal of Pharmaceutics, 259, 143-160 (2003)

[18] 'Role of architecture on the conformation, rheology, and orientation behavior of linear, star, and hyperbranched polymer melts: 2. Linear viscoelasticity and flow birefringence' by S. Kharchenko and R. M. Kannan, Macromolecules, 36(2), 407-415 (2003)

[17] 'Role of architecture on the conformation, rheology, and orientation behavior of linear, star, and hyperbranched polymer melts: 1. Synthesis and Molecular Characterization' by S. Kharchenko, R. M. Kannan, J.Cernohous, and S. Venkataramani, Macromolecules, 36(2), 399-406 (2003)

[16] 'Rheo-optical FTIR Spectroscopy of the deformation behavior in quenched and slow-cooled isotactic polypropylene films', G. Parthasarthy, M. Sevegney, R. M. Kannan, J. Poly. Sci. (Poly. Phys.), 40(22), 2539-2551 (2002)

[15] 'Unusual contributions of molecular architecture to rheology and flow birefringence in hyperbranched polystyrene blends', S. Kharchenko, R. M. Kannan, J. Cernohous, S. Venkataramani, G. Babu, J. Poly. Sci (Poly.Phys), 39, 2562 (2001)

Publications From Graduate and Posdoctoral Work

[14] 'Effect of composition fluctuations on tracer diffusion in symmetric diblock copolymers', R. M. Kannan, T. P. Lodge & J. Su, J. Chem. Phys., 108(11), 4634-4639 (1998)

[13] 'Diffusion in microstructured block copolymer melts.', T. P. Lodge, M. Hamersky, J. Milhaupt, R. M. Kannan, M. C. Dalvi, and C. Eastman, Macromolecular Chem. & Phy., Macro.Symp., Vol. 121, 219 (1997)

[12] 'Viscoelastic properties of highly entangled poly(vinyl methyl ether', R. M. Kannan, T. P. Lodge, Macromolecules, Vol.30 (12), 3694-3695 (1997)

[11] 'Dynamics of disordered diblocks of polyisoprene and polyvinylethylene', B. H. Arendt, R. Krishnamoorti, R. M. Kannan, K. Seitz, J. A. Kornfield & J. Roovers, Macromolecules, 30 (4), 1138-1145 (1997)

[10] 'Effect of mesophase order and molecular weight on the dynamics of nematic and smectic side - group liquid - crystalline polymers', S. F. Rubin, R. M. Kannan, J. A. Kornfield, & C. Boeffel, Macromolecules, Vol. 28(10), 3521 (1995)

[9] 'Evolution of microstructure and viscoelasticity during flow alignment of a lamellar diblock copolymer', R. M. Kannan & J. A. Kornfield, Macromolecules, Vol. 27, 1177-1186 (1994)

[8] 'Stress - optical manifestations of molecular and microstructural dynamics in complex polymer melts', R. M. Kannan & J. A. Kornfield, invited paper, Journal of. Rheology, Vol. 38(4), 1127-1150 (1994)

[7] 'Dynamics of flow-induced alignment of side-group liquid-crystalline polymers. ', R. M. Kannan, S. F. Rubin, J. A. Kornfield, & C. Boeffel, invited paper, J. Rheology, 38(5), 1609-1622 (1994)

[6] 'Shear-induced orientation of side-group liquid-crystalline polymers.', R. M. Kannan, J. A. Kornfield, N. Schwenk, & C. Boeffel, Advanced Materials, Vol. 6, 214-216 (1994)

[5] 'Dynamics of each component in miscible blends of polyisoprene and polyvinylethylene', R. M. Kannan, B. H. Arendt, M. Zewail, & J. A. Kornfield, Rheologica Acta, Vol.33, 322-336 (1994)

[4] 'Dynamics of microstructural alignment of block copolymers during shear.' Kornfield, J. A.; Kannan, R. M. Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) (1993), 34(2), 676-7. [3] 'Rheology of side-group liquid-crystalline polymers:effect of isotropic-nematic transition and evidence of flow alignment', R. M. Kannan, J. A. Kornfield, N. Schwenk, & C. Boeffel, Macromolecules, Vol. 26, 2050 - 2056 (1993)

[2] 'Some thoughts on graduate education-A graduate student's perspective', R. M. Kannan, Chemical Engineering Education, Fall (1992)

[1] 'The third normal stress difference in entangled melts: quantitative stress-optical measurements in oscillatory shear', R. M. Kannan & J. A. Kornfield, Rheologica Acta,Vol.31, 535-544 (1992)


(1) ‘Method of delaminating aggregated particles with a coating agent in a substantially supercritical fluid? E. Gulari, G.K. Serhatkulu, R. M. Kannan, US patent number 7387749 (2007) (2) Method for aligning side-group liquid-crystal polymers. Kornfield, Julia A.; Kannan, Rangaramanujam M.; Schwenk, Norbert. (California Institute of Technology, USA). U.S. patent number 5313320 (1994)

Book Chapters
(1) Kannan, RM., Pillai, O., Kannan, S. Cellular interactions of nano drug delivery systems. In: Force microscopy in biology and medicine, Edited by B.P. Jena, Wiley & Co (in press).

(2) Kannan, RM., Pillai, O., Kannan, S. Dendrimers and hyperbranched polymers for drug delivery. In: Biomedical applications of nanotechnology, Edited by V. Labhasetwar, D.L. Leslie-Pelecky John Wiley & Co (in press).


Selected Invited Talks
[11]Clemson University-Bioengineering, Joint Page Morton Hunter Bioengineering Distinguished Seminar Series & NIH COBRE SCBiomat Lecture Series, Feb, 2010

[10]University of Akron (Polymer Science), December, 2009-Dendrimer nanotherapeutics & neuroinflammation

[9]‘Dendrimer-based nanotherapeutics? Plenary Speaker, Symposium on ‘Nanotechnology in Health Sciences? American Association of Dental Research, Ann Arbor, MI , 12/08

[8]‘Dendrimer-based nanodevice platforms? Invited talks in the following departments at Wayne State University: Obstetrics and Gynecologym (11/08), Perinatology Research Branch (9/08), Immunology and Microbiology (4/08), Institute of Environmental Health Sciences (3/07); Anatomy and Cell Biology (1/07), Pediatric Critical care(12/05), Children’s Hospital of Michigan-PET Center (3/08); pharmaceutical sciences (2006); Karmanos Cancer Institute (2003, 2007, 2009).

[7]‘Designing dendrimer-based nanodevices for intracellular delivery through mechanistic understanding? American Physical Society, April 2007.

[6]‘Emerging nanotechnologies for therapeutic applications? AIChE Nanotechnology forum, November, 2006

[5]‘nanoSEC: experiences from a start-up company? University-Technology Commercialization conference, Dearborn, MI, 9/2006

[4]‘Tailored dendrimer-based nanodevices for targeted drug delivery? ALZA Corporation, California, USA, 5/2005

[3]‘Dendrimer-based bioconjugates as multifunctional targeted drug delivery systems? Invited Plenary lecture, International Polymer Conjugates Conference, Jerusalem, Israel, 12/05

[2]‘Dendrimer-based multi-functional drug delivery nanodevices: from chemistry to clinical applications? American Academy of Nanomedicine at National Academy of Sciences, 9/2006.

[1]‘Dendrimer soft nanoparticles for drug delivery? international particle technology conference, San Diego, 11/2006


(i) Sessions Chaired in National Meetings
[1] APS Meeting, Division High Polymer Physics: Session:Diffusion, March, Los Angeles, 1998

[2] Society of Rheology : Session: Experimental Methods, Columbus, October 1998

[3] APS Meeting, Division of High Polymer Physics: Poster Session, Atlanta, March 1999

[4] AIChE Meeting, Dallas, November 1999: Session: Transport at Fluid Interfaces

[5] AIChE Meeting, Dallas, November 1999: Session: Diffusion in Polymers II

[6] AIChE Meeting, Dallas, November 1999: Session: Adsorption in Thin Films

[7] AIChE Meeting, Los Angeles, 2000, Session: Rheology of Colloidal Dispersions

[8] Polymer Physics Gordon Conference, May 2000, Discussion Leader

[9] AIChE Meeting, Reno, 2001, Structure and Properties of Polymers: Novel Characterization Techniques

[10] AIChE Meeting, Indianapolis, 2002, Structure and Properties of Polymers

Participated in NSF Review Panels : NIRT Biomaterials Panel (2001): NSF- CCLI (2001); NSF- CCLI (2002)

(ii) WSU Materials Science Program: Graduate Advisor : (2000 ?current)

(ii) WSU Committee Assignments
Curriculum Planning: Design, Ethics, and Professionalism, Engineering (1998)

AOC –department representative (1998-2000)

Shops Committee (2001- 2003)

Member of the CHE LAB improvement committee-Took part in the proposal writing, purchase and set-up of the some of the new experiments in the ChE 3220 lab

College of Engineering Representative on the Advisory Board for the Office of Teaching and Learning (OTL) at WSU.