Publication Date Title Authors Publication Link
2017 Trajectory of inflammatory and microglial activation markers in the postnatal rabbit brain following intrauterine endotoxin exposure Zhang Z, Jyoti A, Balakrishnan B, Williams M, Singh S, Chugani DC, Kannan S Neurobiology of Disease
2017 Dendrimer-mediated delivery of N-acetyl cysteine to microglia in a mouse model of Rett syndrome Nance E, Kambhampati SP, Smith ES, Zhang Z, Zhang F, Singh S, Johnston MV, Kannan RM, Blue ME, Kannan S Journal of Neuroinflammation
2017 Activated Microglia Targeting Dendrimer-Minocycline Conjugate as Therapeutics for Neuroinflammation Sharma R, Kim SY, Sharma A, Zhang Z, Kambhampati SP, Kannan S, Kannan RM Bioconjugate Chemistry
2017 Supercritical carbon dioxide (scCO2) dispersion of poly(ethylene terephthalate)/clay nanocomposites: Structural, mechanical, thermal, and barrier properties F Yang, C Mubarak, R Keiegel, R Kannan Journal of Applied Polymer Science
2017 Microglia activation in a pediatric rabbit model of tuberculous meningitis E Tucker, S Pokkali, Z Zhang, V DeMarco, M Klunk, E Smith, A Ordonez, M Penet, Z Bhujwalla, S Jain, S Kannan Disease Models and Mechanisms
2017 Maternal Inflammation Results in Altered Tryptophan Metabolism in Rabbit Placenta and Fetal Brain M Williams, Z Zhang, E Nance, J Drewes, W Lesniak, S Singh, D Chugani, K Rangaramanujam, D Graham, S Kannan Developmental Neuroscience
2017 Maternal dendrimer-based therapy for inflammation-induced preterm birth and perinatal brain injury J Lei, J Rosenzweig, M Mishra, W Alshehri, F Brancusi, M McLane, A Almalki, R Bahabry, H Arif, R Rozzah, G Alyousif, Y Shabi, N Alhehaily, W Zhong, A Facciabene, S Kannan, R Kannan, I Burd Scientific Reports
2017 Uptake of dendrimer-drug by different cell types in the hippocampus after hypoxic-ischemic insult in neonatal mice: Effects of injury, microglial activation and hypothermia C Nemeth, G Drummond, M Mishra, F Zhang, P Carr, M Garcia, S Doman, A Fatemi, M Johnston, R Kannan, S Kannan, M Wilson Nanomedicine: Nanotechnology, Biology and Medicine
2016 Maternal inflammation leads to impaired glutamate homeostasis and up-regulation of glutamate carboxypeptidase II in activated microglia in the fetal/newborn rabbit brain Z Zhang, B Bassam, A Thomas, M Williams, J Liu, E Nance, C Rojas, B Slusher, S Kannan Neurobiology of Disease
2016 Selective Localization of a Novel Dendrimer Nanoparticle in Myocardial Ischemia-Reperfusion Injury J Magruder, T Crawford, Y Lin, F Zhang, J Grimm, R Kannan, S Kannan, C Sciortino Annals of Thoracic Surgery
2016 Subconjunctival injectable dendrimer-dexamethasone gel for the treatment of corneal inflammation U Soiberman, S Kambhampati, T Wu, M Mishra, Y Oh, R Sharma, J Wang, A Al Towerki, S Yiu, W Stark, R Kannan Biomaterials
2016 Dendrimers Target the Ischemic Lesion in Rodent and Primate Moedls of Nonarteritic Anterior Ischemic Optic Neuropathy Y Guo, M Johnson, Z Mehrabian, M Mishra, R Kannan, N Miller, S Berstein PlosONE
2016 Generation-6 hydroxyl PAMAM dendrimers improve CNS penetration from intravenous administration in a large animal brain injury model F Zhang, J Trent Magruder, Y Lin, T Crawford, J Grimm, C Sciortino, M Wilson, M Blue, S Kannan, M Johnston, W Baumgartner, R Kannan Journal of Controlled Release
2016 Surface functionality affects the biodistribution and microglia-targeting of intra-amniotically delivered dendrimers F Zhang, E Nance, Z Zhang, V Jasty, S Kambhampati, M Mishra, I Burd, R Romero, S Kannan, R Kannan Journal of Controlled Release
2016 Nanoscale effects in dendrimer-mediated targeting of neuroinflammation in newborn brain injury E Nance, F Zhang, M Mishra, Z Zhang, S Kambhampati, R Kannan, S Kannan Biomaterials
2016 Nanotechnology Approaches to Targeting Inflammation and Excitotoxicity in a Canine Model of Hypothermic Circulatory Arrest–Induced Brain Injury J Grimm, J Magruder, M Wilson, M Blue, T Crawford, J Troncoso, F Zhang, S Kannan, C Sciortino, M Johnston, R Kannan, A Baumgartner The Annals of Thoracic Surgery
2016 Uniform brain tumor distribution and tumor associated macrophage targeting of systemically administered dendrimers F Zhang, P Mastorakos, M Mishra, A Mangraviti, J Zhou, J Hanes, H Brem, A Olivi, B Tyler, R Kannan Biomaterials
2016 Intracellular delivery of dendrimer triamcinolone acetonide conjugates into microgllial and human retinal pigment epithelial cells S Kambhampati, M Mishra, P Mastorakos, Y Oh, G Lutty, R Kannan Eur J Pharm Biopharm
2015 Targeting specific cells in the brain with nanomedicines for CNS therapies F Zhang, Y Lin, S Kannan, R Kannan Journal of Controlled Release
2015 Dendrimer-enabled transformation of Anaplasma phagocytophilum A Oki, D Seidman, M Lancina, M Mishra, R Kannan, H Yang, J Carlyon Microbes and Infection
2015 In vivo bone formation by and inflammatory response to resorbable polymer-nanoclay constructs K Baker, T Maerz, H Saad, P Shaheen, R Kannan Nanomedicine: Nanotechnology, Biology, and Medicine
2015 Systemic and intravitreal delivery of dendrimers to activated microglia/macrophage in ischemia/reperfusion mouse retina S Kambhampati, A Clunies-Ross, I Bhutto, M Mishra, M Edwards, D McLeod, R Kannan, G Lutty Investigative Ophthalmology and Visual Science
2015 Systemic dendrimer-drug treatment of ischemia-induced neonatal white matter injury E Nance, M Porambo, F Zhang, M Mishra, M Buelow, R Getzenberg, M Johnston, R Kannan, A Fatemi, S Kannan Journal of Controlled Release
2015 Hydroxyl PAMAM dendrimer-based gene vectors for transgene delivery to human retinal pigment epithelial cells P Mastorakos, S Kambhampati, M Mishra, T Wu, E Song, J Hanes, R Kannan Nanoscale
2014 Emerging concepts in dendrimer-based nanomedicine: From design principles to clinical applications R Kannan, E Nance, S Kannan, D Tomalia Journal of Internal Medicine
2014 Fetal uptake of intra-amniotically delivered dendrimers in a mouse model of intrauterine inflammation and preterm birth I Burd, F Zhang, T Dada, M Mishra, T Borbiev, W Lesniak, H Baghlaf, S Kannan, R Kannan Nanomedicine: Nanotechnology, Biology, and Medicine
2014 Folate-functionalized dendrimers for targeting Chlamydia-infected tissues in a mouse model of reactive arthritis I Benchaala, M Mishra, S Wykes, M Hali, R Kannan, J Whittum-Hudson International Journal of Pharmaceutics
2014 Dendrimer Brain Uptake and Targeted Therapy for Brain Injury in a Large Animal Model of Hypothermic Circulatory Arrest M Mishra, C Beaty, W Lesniak, S Kambhampati, F Zhang, M Wilson, M Blue, J Troncoso, S Kannan, M Johnston, W Baumgartner, R Kannan ACS Nano
2013 Nanomedicine in cerebral palsy B Balakrishnan, E Nance, MV Johnston, RM Kannan, S Kannan International Journal of Nanomedicine
2013 Biodistribution of Fluorescently-labeled PAMAM Dendrimers in Neonatal Rabbits: Effect of Neuroinflammation W Lesniak, MK Mishra, A Jyoti, B Balakrishnan, F Zhang, E Nance, R Romero, S Kannan, RM Kannan Molecular Pharmaceutics
2013 Concurrent quantification of tryptophan and its major metabolites WG Lesniak, A Jyoti, MK Mishra, N Louissaint, R Romero, DC Chugani, S Kannan, RM Kannan Analytical Biochemistry
2013 Dendrimer-enabled transformation of Chlamydia trachomatis RM Kannan, HC Gerard, MK Mishra, G Mao, S Wang, M Hali, JA Whittum-Hudson, AP Hudson Microbial Pathogenesis
2013 Dendrimer-enabled DNA delivery and transformation of Chlamydia pneumoniae HC Gerard, MK Mishra, G Mao, S Wang, M Hali, JA Whittum-Hudson, RM Kannan, AP Hudson Nanomedicine: Nanotechnology, Biology, and Medicine
2013 Dendrimer nanoparticles for ocular drug delivery SP Kambhampati, RM Kannan Journal of Ocular Pharmacology and Therapeutics
2013 Nanotechnology approaches for ocular drug delivery Q Xu, SP Kambhampati, RM Kannan Middle East African Journal of Ophthalmology
2013 Use of Single-Site-Functionalized PEG Dendrons To Prepare Gene Vectors that Penetrate Human Mucus Barriers AJ Kim, NJ Boylan, JS Suk, M Hwangbo, T Yu, BS Schuster, L Cebotaru, WG Lesniak, JS Oh, P Adstamongkonkul, AY Choi, RM Kannan, J Hanes Angew Chem Int Ed Engl
2013 Enhancing the efficacy of Ara-C through conjugation with PAMAM dendrimer and linear PEG: a comparative study UH Sk, SP Kambhampati, MK Mishra, WG Lesniak, F Zhang, RM Kannan Biomacromolecules
2012 Dendrimer-based postnatal therapy for neuroinflammation and cerebral palsy in a rabbit model S Kannan, H Dai, RS Navath, B Balakrishnan, A Jyoti, J Janisse, R Romero, RM Kannan Science Translational Medicine
2012 Dendrimer-based targeted intravitreal therapy for sustained attenuation of neuroinflammation in retinal degeneration R Iezzi. B Guru, I Glybina, M Mishra, A Kennedy, R Kannan Biomaterials
2012 A dendrimer-based immunosensor for improved capture and detection of tumor necrosis factor-alpha cytokine A Bosnjakovic, MK Mishra, HJ Han, R Romero, RM Kannan Biomaterials
2012 Dendrimer-enabled modulation of gene expression in Chlamydia trachomatis MK Mishra, HC Gerard, JA Whittum-Hudson, AP Hudson, RM Kannan Molecular Pharmaceutics
2011 Injectable PAMAM dendrimer-PEG hydrogels for the treatment of genital infections: formulation and in vitro and in vivo evaluation RS Navath, AR Menjoge, H Dai, R Romero, S Kannan, RM Kannan Molecular Pharmaceutics
2011 PAMAM dendrimer-azithromycin conjugate nanodevices for the treatment of Chlamydia trachomatis infections MK Mishra, K Kotta, M Hali, S Wykes, HC Gerard, AP Hudson, JA Whittum-Hudson, RM Kannan Nanomedicine: Nanotechnology, Biology, and Medicine
2011 Transfer of PAMAM dendrimers across human placenta: Prospects of its use as drug carrier during pregnancy AR Menjoge, AL Rinderknecht, RS Navath, M Faridnia, CJ Kim, R Romero, RK Miller, RM Kannan Journal of Controlled Release
2011 Poly(amidoamine) dendrimer-erythromycin conjugates for drug delivery to macrophages involved in periprosthetic inflammation A Bosnjakovic, MK Mishra, W Ren, YE Kurtoglu, T Shi, D Fan, RM Kannan Nanomedicine: Nanotechnology, Biology, and Medicine
2010 Intrinsic targeting of inflammatory cells in the brain by polyamidoamine dendrimers upon subarachnoid administration H Dai, RS Navath, B Balakrishnan, BR Guru, MK Mishra, R Romero, RM Kannan, S Kannan Nanomedicine: Nanotechnology, Biology, and Medicine
2010 In vivo efficacy of dendrimer-methylprednisolone conjugate formulation for the treatment of lung inflammation R Inapagolla, BR Guru, YE Kurtoglu, X Gao, M Lieh-Lai, DJ Bassett, RM Kannan International Journal of Pharmaceutics
2010 Inhibition of bacterial growth and intramniotic infection in a guinea pig model of chorioamnionitis using PAMAM dendrimers B Wang, RS Navath, AR Menjoge, B Balakrishnan, R Bellair, H Dai, R Romero, S Kannan, RM Kannan International Journal of Pharmaceutics
2010 Amino Acid-Functionalized Dendrimers with Heterobifunctional Chemoselective Peripheral Groups for Drug Delivery Applications RS Navath, AR Menjoge, B Wang, R Romero, S Kannan, RM Kannan Biomacromolecules
2010 Transport and biodistribution of dendrimers across human fetal membranes: Implications for intravaginal administration of dendrimer-drug conjugates AR Menjoge, RS Navath, A Asad, S Kannan, CJ Kim, R Romero, RM Kannan Biomaterials
2010 Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications AR Menjoge, RM Kannan, DA Tomalia Drug Discovery Today
2010 Stimuli-responsive star poly(ethylene glycol) drug conjugates for improved intracellular delivery of the drug in neuroinflammation RS Navath, B Wang, S Kannan, R Romero, RM Kannan Journal of Controlled Release
2010 Multifunctional Dendrimer-Templated Antibody Presentation on Biosensor Surfaces for Improved Biomarker Detection HJ Han, RM Kannan, SX Wang, GZ Mao, JP Kusanovic, R Romero Advanced Functional Materials
2010 Drug release characteristics of PAMAM dendrimer-drug conjugates with different linkers YE Kurtoglu, MK Mishra, S Kannan, RM Kannan International Journal of Pharmaceutics
2009 Anti-inflammatory and anti-oxidant activity of anionic dendrimer-N-acetyl cysteine conjugates in activated microglial cells B Wang, RS Navath, R Romero, S Kannan, R Kannan International Journal of Pharmaceutics
2009 Effects of Branching Architecture and Linker on the Activity of Hyperbranched Polymer-Drug Conjugates O Perumal, J Khandare, P Kolhe, S Kannan, M Lieh-Lai, RM Kannan Bioconjugate Chemistry
2009 Poly(amidoamine) dendrimer-drug conjugates with disulfide linkages for intracellular drug delivery YE Kurtoglu, RS Navath, B Wang, S Kannan, R Romero, RM Kannan Biomaterials
2008 Dendrimer-drug conjugates for tailored intracellular drug release based on glutathione levels RS Navath, YE Kurtoglu, B Wang, S Kannan, R Romero, RM Kannan Bioconjugate Chemistry
2008 The effect of surface functionality on cellular trafficking of dendrimers OP Perumal, R Inapagolla, S Kannan, RM Kannan Biomaterials
2007 Synthesis, characterization and in vitro release of dendrimer-streptokinase conjugates X. Wang, R. Inapagolla, M. Lieh-Lai, R. M. Kannan, S. Kannan Bioconjugate Chemistry
2006 Preparation, cellular transport, and activity of polyamidoamine-based dendritic nanodevices with a high drug payload P. Kolhe, J. Khandare, O. Pillai, S. Kannan, M. Lieh-Lai, R. M. Kannan Biomaterials
2005 Synthesis, Cellular Transport and Activity of PAMAM Dendrimer-Methylprednisolone Conjugates J. Khandare, P. Kolhe, O. Pillai, S. Kannan, M. Lieh-Lai, R. M. Kannan Bioconjugate Chemistry
2005 Activity of dendrimer-methotrexate conjugates in sensitive and resistant cell lines S. Gurdag, J. Khandare, S. Staples, R. M. Kannan, L. Matherly Bioconjugate Chemistry
2004 Hyperbranched polymer-drug conjugates with high drug payload for enhanced cellular delivery P. Kolhe, J. Khandare, O. Pillai, S. Kannan, M. Lieh-Lai, R. M. Kannan Pharm. Research
2004 Effect of dendrimer end functionality on the cytotoxicity and the cellular drug delivery in lung epithelial cells S. Kannan, P. Kolhe, R. M. Kannan, M. Lieh-lai, M. Glibatec Journal of Biomaterials Science: Polymers Edition
2003 Drug complexation, in vitro release, and cellular entry by dendrimers and hyperbranched polymers P. Kohle, E. Misra, R. M.Kannan, S. Kannan, M. Lieh-Lai International Journal of Pharmaceutics