Publications

Publication Date Title Authors Publication Link
2017 Supercritical carbon dioxide (scCO2) dispersion of poly(ethylene terephthalate)/clay nanocomposites: Structural, mechanical, thermal, and barrier properties F Yang, C Mubarak, R Keiegel, R Kannan Journal of Applied Polymer Science
2017 Microglia activation in a pediatric rabbit model of tuberculous meningitis E Tucker, S Pokkali, Z Zhang, V DeMarco, M Klunk, E Smith, A Ordonez, M Penet, Z Bhujwalla, S Jain, S Kannan Disease Models and Mechanisms
2017 Maternal Inflammation Results in Altered Tryptophan Metabolism in Rabbit Placenta and Fetal Brain M Williams, Z Zhang, E Nance, J Drewes, W Lesniak, S Singh, D Chugani, K Rangaramanujam, D Graham, S Kannan Developmental Neuroscience
2017 Maternal dendrimer-based therapy for inflammation-induced preterm birth and perinatal brain injury J Lei, J Rosenzweig, M Mishra, W Alshehri, F Brancusi, M McLane, A Almalki, R Bahabry, H Arif, R Rozzah, G Alyousif, Y Shabi, N Alhehaily, W Zhong, A Facciabene, S Kannan, R Kannan, I Burd Scientific Reports
2017 Uptake of dendrimer-drug by different cell types in the hippocampus after hypoxic-ischemic insult in neonatal mice: Effects of injury, microglial activation and hypothermia C Nemeth, G Drummond, M Mishra, F Zhang, P Carr, M Garcia, S Doman, A Fatemi, M Johnston, R Kannan, S Kannan, M Wilson Nanomedicine: Nanotechnology, Biology and Medicine
2016 Maternal inflammation leads to impaired glutamate homeostasis and up-regulation of glutamate carboxypeptidase II in activated microglia in the fetal/newborn rabbit brain Z Zhang, B Bassam, A Thomas, M Williams, J Liu, E Nance, C Rojas, B Slusher, S Kannan Neurobiology of Disease
2016 Selective Localization of a Novel Dendrimer Nanoparticle in Myocardial Ischemia-Reperfusion Injury J Magruder, T Crawford, Y Lin, F Zhang, J Grimm, R Kannan, S Kannan, C Sciortino Annals of Thoracic Surgery
2016 Subconjunctival injectable dendrimer-dexamethasone gel for the treatment of corneal inflammation U Soiberman, S Kambhampati, T Wu, M Mishra, Y Oh, R Sharma, J Wang, A Al Towerki, S Yiu, W Stark, R Kannan Biomaterials
2016 Dendrimers Target the Ischemic Lesion in Rodent and Primate Moedls of Nonarteritic Anterior Ischemic Optic Neuropathy Y Guo, M Johnson, Z Mehrabian, M Mishra, R Kannan, N Miller, S Berstein PlosONE
2016 Generation-6 hydroxyl PAMAM dendrimers improve CNS penetration from intravenous administration in a large animal brain injury model F Zhang, J Trent Magruder, Y Lin, T Crawford, J Grimm, C Sciortino, M Wilson, M Blue, S Kannan, M Johnston, W Baumgartner, R Kannan Journal of Controlled Release
2016 Surface functionality affects the biodistribution and microglia-targeting of intra-amniotically delivered dendrimers F Zhang, E Nance, Z Zhang, V Jasty, S Kambhampati, M Mishra, I Burd, R Romero, S Kannan, R Kannan Journal of Controlled Release
2016 Nanoscale effects in dendrimer-mediated targeting of neuroinflammation in newborn brain injury E Nance, F Zhang, M Mishra, Z Zhang, S Kambhampati, R Kannan, S Kannan Biomaterials
2016 Nanotechnology Approaches to Targeting Inflammation and Excitotoxicity in a Canine Model of Hypothermic Circulatory Arrest–Induced Brain Injury J Grimm, J Magruder, M Wilson, M Blue, T Crawford, J Troncoso, F Zhang, S Kannan, C Sciortino, M Johnston, R Kannan, A Baumgartner The Annals of Thoracic Surgery
2016 Uniform brain tumor distribution and tumor associated macrophage targeting of systemically administered dendrimers F Zhang, P Mastorakos, M Mishra, A Mangraviti, J Zhou, J Hanes, H Brem, A Olivi, B Tyler, R Kannan Biomaterials
2016 Intracellular delivery of dendrimer triamcinolone acetonide conjugates into microgllial and human retinal pigment epithelial cells S Kambhampati, M Mishra, P Mastorakos, Y Oh, G Lutty, R Kannan Eur J Pharm Biopharm
2015 Targeting specific cells in the brain with nanomedicines for CNS therapies F Zhang, Y Lin, S Kannan, R Kannan Journal of Controlled Release
2015 Dendrimer-enabled transformation of Anaplasma phagocytophilum A Oki, D Seidman, M Lancina, M Mishra, R Kannan, H Yang, J Carlyon Microbes and Infection
2015 In vivo bone formation by and inflammatory response to resorbable polymer-nanoclay constructs K Baker, T Maerz, H Saad, P Shaheen, R Kannan Nanomedicine: Nanotechnology, Biology, and Medicine
2015 Systemic and intravitreal delivery of dendrimers to activated microglia/macrophage in ischemia/reperfusion mouse retina S Kambhampati, A Clunies-Ross, I Bhutto, M Mishra, M Edwards, D McLeod, R Kannan, G Lutty Investigative Ophthalmology and Visual Science
2015 Systemic dendrimer-drug treatment of ischemia-induced neonatal white matter injury E Nance, M Porambo, F Zhang, M Mishra, M Buelow, R Getzenberg, M Johnston, R Kannan, A Fatemi, S Kannan Journal of Controlled Release
2015 Hydroxyl PAMAM dendrimer-based gene vectors for transgene delivery to human retinal pigment epithelial cells P Mastorakos, S Kambhampati, M Mishra, T Wu, E Song, J Hanes, R Kannan Nanoscale
2014 Emerging concepts in dendrimer-based nanomedicine: From design principles to clinical applications R Kannan, E Nance, S Kannan, D Tomalia Journal of Internal Medicine
2014 Fetal uptake of intra-amniotically delivered dendrimers in a mouse model of intrauterine inflammation and preterm birth I Burd, F Zhang, T Dada, M Mishra, T Borbiev, W Lesniak, H Baghlaf, S Kannan, R Kannan Nanomedicine: Nanotechnology, Biology, and Medicine
2014 Folate-functionalized dendrimers for targeting Chlamydia-infected tissues in a mouse model of reactive arthritis I Benchaala, M Mishra, S Wykes, M Hali, R Kannan, J Whittum-Hudson International Journal of Pharmaceutics
2014 Dendrimer Brain Uptake and Targeted Therapy for Brain Injury in a Large Animal Model of Hypothermic Circulatory Arrest M Mishra, C Beaty, W Lesniak, S Kambhampati, F Zhang, M Wilson, M Blue, J Troncoso, S Kannan, M Johnston, W Baumgartner, R Kannan ACS Nano
2013 Nanomedicine in cerebral palsy B Balakrishnan, E Nance, MV Johnston, RM Kannan, S Kannan International Journal of Nanomedicine
2013 Biodistribution of Fluorescently-labeled PAMAM Dendrimers in Neonatal Rabbits: Effect of Neuroinflammation W Lesniak, MK Mishra, A Jyoti, B Balakrishnan, F Zhang, E Nance, R Romero, S Kannan, RM Kannan Molecular Pharmaceutics
2013 Concurrent quantification of tryptophan and its major metabolites WG Lesniak, A Jyoti, MK Mishra, N Louissaint, R Romero, DC Chugani, S Kannan, RM Kannan Analytical Biochemistry
2013 Dendrimer-enabled transformation of Chlamydia trachomatis RM Kannan, HC Gerard, MK Mishra, G Mao, S Wang, M Hali, JA Whittum-Hudson, AP Hudson Microbial Pathogenesis
2013 Dendrimer-enabled DNA delivery and transformation of Chlamydia pneumoniae HC Gerard, MK Mishra, G Mao, S Wang, M Hali, JA Whittum-Hudson, RM Kannan, AP Hudson Nanomedicine: Nanotechnology, Biology, and Medicine
2013 Dendrimer nanoparticles for ocular drug delivery SP Kambhampati, RM Kannan Journal of Ocular Pharmacology and Therapeutics
2013 Nanotechnology approaches for ocular drug delivery Q Xu, SP Kambhampati, RM Kannan Middle East African Journal of Ophthalmology
2013 Use of Single-Site-Functionalized PEG Dendrons To Prepare Gene Vectors that Penetrate Human Mucus Barriers AJ Kim, NJ Boylan, JS Suk, M Hwangbo, T Yu, BS Schuster, L Cebotaru, WG Lesniak, JS Oh, P Adstamongkonkul, AY Choi, RM Kannan, J Hanes Angew Chem Int Ed Engl
2013 Enhancing the efficacy of Ara-C through conjugation with PAMAM dendrimer and linear PEG: a comparative study UH Sk, SP Kambhampati, MK Mishra, WG Lesniak, F Zhang, RM Kannan Biomacromolecules
2012 Dendrimer-based postnatal therapy for neuroinflammation and cerebral palsy in a rabbit model S Kannan, H Dai, RS Navath, B Balakrishnan, A Jyoti, J Janisse, R Romero, RM Kannan Science Translational Medicine
2012 Dendrimer-based targeted intravitreal therapy for sustained attenuation of neuroinflammation in retinal degeneration R Iezzi. B Guru, I Glybina, M Mishra, A Kennedy, R Kannan Biomaterials
2012 A dendrimer-based immunosensor for improved capture and detection of tumor necrosis factor-alpha cytokine A Bosnjakovic, MK Mishra, HJ Han, R Romero, RM Kannan Biomaterials
2012 Dendrimer-enabled modulation of gene expression in Chlamydia trachomatis MK Mishra, HC Gerard, JA Whittum-Hudson, AP Hudson, RM Kannan Molecular Pharmaceutics
2011 Injectable PAMAM dendrimer-PEG hydrogels for the treatment of genital infections: formulation and in vitro and in vivo evaluation RS Navath, AR Menjoge, H Dai, R Romero, S Kannan, RM Kannan Molecular Pharmaceutics
2011 PAMAM dendrimer-azithromycin conjugate nanodevices for the treatment of Chlamydia trachomatis infections MK Mishra, K Kotta, M Hali, S Wykes, HC Gerard, AP Hudson, JA Whittum-Hudson, RM Kannan Nanomedicine: Nanotechnology, Biology, and Medicine
2011 Transfer of PAMAM dendrimers across human placenta: Prospects of its use as drug carrier during pregnancy AR Menjoge, AL Rinderknecht, RS Navath, M Faridnia, CJ Kim, R Romero, RK Miller, RM Kannan Journal of Controlled Release
2011 Poly(amidoamine) dendrimer-erythromycin conjugates for drug delivery to macrophages involved in periprosthetic inflammation A Bosnjakovic, MK Mishra, W Ren, YE Kurtoglu, T Shi, D Fan, RM Kannan Nanomedicine: Nanotechnology, Biology, and Medicine
2010 Intrinsic targeting of inflammatory cells in the brain by polyamidoamine dendrimers upon subarachnoid administration H Dai, RS Navath, B Balakrishnan, BR Guru, MK Mishra, R Romero, RM Kannan, S Kannan Nanomedicine: Nanotechnology, Biology, and Medicine
2010 In vivo efficacy of dendrimer-methylprednisolone conjugate formulation for the treatment of lung inflammation R Inapagolla, BR Guru, YE Kurtoglu, X Gao, M Lieh-Lai, DJ Bassett, RM Kannan International Journal of Pharmaceutics
2010 Inhibition of bacterial growth and intramniotic infection in a guinea pig model of chorioamnionitis using PAMAM dendrimers B Wang, RS Navath, AR Menjoge, B Balakrishnan, R Bellair, H Dai, R Romero, S Kannan, RM Kannan International Journal of Pharmaceutics
2010 Amino Acid-Functionalized Dendrimers with Heterobifunctional Chemoselective Peripheral Groups for Drug Delivery Applications RS Navath, AR Menjoge, B Wang, R Romero, S Kannan, RM Kannan Biomacromolecules
2010 Transport and biodistribution of dendrimers across human fetal membranes: Implications for intravaginal administration of dendrimer-drug conjugates AR Menjoge, RS Navath, A Asad, S Kannan, CJ Kim, R Romero, RM Kannan Biomaterials
2010 Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications AR Menjoge, RM Kannan, DA Tomalia Drug Discovery Today
2010 Stimuli-responsive star poly(ethylene glycol) drug conjugates for improved intracellular delivery of the drug in neuroinflammation RS Navath, B Wang, S Kannan, R Romero, RM Kannan Journal of Controlled Release
2010 Multifunctional Dendrimer-Templated Antibody Presentation on Biosensor Surfaces for Improved Biomarker Detection HJ Han, RM Kannan, SX Wang, GZ Mao, JP Kusanovic, R Romero Advanced Functional Materials
2010 Drug release characteristics of PAMAM dendrimer-drug conjugates with different linkers YE Kurtoglu, MK Mishra, S Kannan, RM Kannan International Journal of Pharmaceutics
2009 Anti-inflammatory and anti-oxidant activity of anionic dendrimer-N-acetyl cysteine conjugates in activated microglial cells B Wang, RS Navath, R Romero, S Kannan, R Kannan International Journal of Pharmaceutics
2009 Effects of Branching Architecture and Linker on the Activity of Hyperbranched Polymer-Drug Conjugates O Perumal, J Khandare, P Kolhe, S Kannan, M Lieh-Lai, RM Kannan Bioconjugate Chemistry
2009 Poly(amidoamine) dendrimer-drug conjugates with disulfide linkages for intracellular drug delivery YE Kurtoglu, RS Navath, B Wang, S Kannan, R Romero, RM Kannan Biomaterials
2008 Dendrimer-drug conjugates for tailored intracellular drug release based on glutathione levels RS Navath, YE Kurtoglu, B Wang, S Kannan, R Romero, RM Kannan Bioconjugate Chemistry
2008 The effect of surface functionality on cellular trafficking of dendrimers OP Perumal, R Inapagolla, S Kannan, RM Kannan Biomaterials
2007 Synthesis, characterization and in vitro release of dendrimer-streptokinase conjugates X. Wang, R. Inapagolla, M. Lieh-Lai, R. M. Kannan, S. Kannan Bioconjugate Chemistry
2006 Preparation, cellular transport, and activity of polyamidoamine-based dendritic nanodevices with a high drug payload P. Kolhe, J. Khandare, O. Pillai, S. Kannan, M. Lieh-Lai, R. M. Kannan Biomaterials
2005 Synthesis, Cellular Transport and Activity of PAMAM Dendrimer-Methylprednisolone Conjugates J. Khandare, P. Kolhe, O. Pillai, S. Kannan, M. Lieh-Lai, R. M. Kannan Bioconjugate Chemistry
2005 Activity of dendrimer-methotrexate conjugates in sensitive and resistant cell lines S. Gurdag, J. Khandare, S. Staples, R. M. Kannan, L. Matherly Bioconjugate Chemistry
2004 Hyperbranched polymer-drug conjugates with high drug payload for enhanced cellular delivery P. Kolhe, J. Khandare, O. Pillai, S. Kannan, M. Lieh-Lai, R. M. Kannan Pharm. Research
2004 Effect of dendrimer end functionality on the cytotoxicity and the cellular drug delivery in lung epithelial cells S. Kannan, P. Kolhe, R. M. Kannan, M. Lieh-lai, M. Glibatec Journal of Biomaterials Science: Polymers Edition
2003 Drug complexation, in vitro release, and cellular entry by dendrimers and hyperbranched polymers P. Kohle, E. Misra, R. M.Kannan, S. Kannan, M. Lieh-Lai International Journal of Pharmaceutics